Several natural and synthetic coumarins and derivatives with potent in vivo/in vitro biological responses appear to be promising anticancer activities. In addition to selected biological data, a wide range of pharmaceutical applications and pharmaceutical compositions are also summarized. antimitotic, immunomodulating, antiviral, anticancer and cytotoxic agents, as well as some new biological assays, are included. Synthesis, combinatorial techniques, biological evaluation in vitro/in vivo/ex vivo, e.g. In this review recent patent publications (2008 – 2011), describing coumarins and their derivatives, are analyzed. Their physicochemical properties seem to define the extent of the biological activity. ![]() ![]() ![]() They belong to the benzopyrones family and possess a wide variety of cytoprotective and modulatory functions, which may be translated to therapeutic potentials for multiple diseases. Coumarins are a group of plant-derived polyphenolic compounds.
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